Article
Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel.
Diabetes - 1 Sept 2015
Salisbury Rachel J, Han Bing, Jennings Rachel E, Berry Andrew A, Stevens Adam, Mohamed Zainab, Sugden Sarah A, De Krijger Ronald, Cross Sarah E, Johnson Paul P V, Newbould Melanie, Cosgrove Karen E, Hanley Karen Piper, Banerjee Indraneel, Dunne Mark J, Hanley Neil A
Abstract excerpt
Diffuse congenital hyperinsulinism in infancy (CHI-D) arises from mutations inactivating the KATP channel; however, the phenotype is difficult to explain from electrophysiology alone. Here we studied wider abnormalities in the β-cell and other pancreatic lineages. Islets were disorganized in CHI-D compared with controls. PAX4 and ARX expression was decreased. A tendency toward increased NKX2.2 expression was...
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