Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution.

doi:10.1128/JVI.01745-13

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution.

Journal of virology - 1 Jan 2014

Brown Richard J P, Koutsoudakis George, Urbanowicz Richard A, Mirza Deeman, Ginkel Corinne, Riebesehl Nina, Calland Noémie, Albecka Anna, Price Louisa, Hudson Natalia, Descamps Véronique, Backx Matthijs, McClure C Patrick, Duverlie Gilles, Pecheur Eve-Isabelle, Dubuisson Jean, Perez-del-Pulgar Sofia, Forns Xavier, Steinmann Eike, Tarr Alexander W, Pietschmann Thomas, Ball Jonathan K

Abstract excerpt

Serine is encoded by two divergent codon types, UCN and AGY, which are not interchangeable by a single nucleotide substitution. Switching between codon types therefore occurs via intermediates (threonine or cysteine) or via simultaneous tandem substitutions. Hepatitis C virus (HCV) chronically infects 2 to 3% of the global population. The highly variable glycoproteins E1 and E2 decorate the surface of the viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to UCN gene

Share to Glycoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24173227
DOI: 10.1128/JVI.01745-13
PMCID: PMC3911737

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution.PMID 24173227Read ↗

Evolutionary switches between two serine codon sets are driven by selection.Semantic proximity Read ↗

Synonymous mutations in viral evolution and vaccine design.Semantic proximity Read ↗

Genetic Evolution and Molecular Selection of the HE Gene of Influenza C VirusSemantic proximity Read ↗

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.Semantic proximity Read ↗

High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progression.Semantic proximity Read ↗

Differential selection in HIV-1 gp120 between subtype B and East Asian variant B'.Semantic proximity Read ↗

Dissecting the evolutionary forces shaping codon usage bias in SFTSV from eastern China: Insights from a previously underrepresented region.Semantic proximity Read ↗

The Critical Role of Codon Composition on the Translation Efficiency Robustness of the Hepatitis A Virus CapsidSemantic proximity Read ↗

Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2.Semantic proximity Read ↗

Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.Semantic proximity Read ↗

Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes.Semantic proximity Read ↗

The genetic divergences of codon usage shed new lights on transmission of hepatitis E virus from swine to humanSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.