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Article

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

30 Mar 2008

Abstract excerpt

OBJECTIVES: Toll-like receptors (TLR) are important in pathogen recognition and may play a role in HIV disease. We evaluated the effect of chronic untreated and treated HIV-1 infection on systemic TLR expression and TLR signalling. METHODS: Two hundred HIV-infected and uninfected women from a Kenya cohort participated in the studies. TLR1 to TLR10 messenger RNA expression was determined by quantitative reverse...

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PMID: 18356597
DOI: 10.1097/qad.0b013e3282f4de35

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