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Article

Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.

Journal of virology - 1 Jan 2017

Takahashi Kenta, Sekizuka Tsuyoshi, Fukumoto Hitomi, Nakamichi Kazuo, Suzuki Tadaki, Sato Yuko, Hasegawa Hideki, Kuroda Makoto, Katano Harutaka

Abstract excerpt

JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencing. A mutation from A to C at nucleotide (nt) 3495 in JCV Mad1 resulting in a V-to-G amino acid substitution at amino acid (aa)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27795410
DOI: 10.1128/JVI.01335-16
PMCID: PMC5165223

Genes

PML

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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