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Article

Molecular characterization of JC virus in progressive multifocal leukoencephalopathy cases from India.

Scientific reports - 1 Dec 2025

Palani Gnana Soundari, Telang Surbhi, Reddy Vijayalakshmi, Dhanya K, Ashwini M A, Mani Reeta S

Abstract excerpt

Progressive Multifocal Leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system caused by reactivation of the John Cunningham virus (JCV) in immunocompromised individuals. Despite an estimated 2.4 million people living with HIV in India, the reported incidence of PML remains lower than in Western countries, likely due to underdiagnosis, underreporting, and distinct host...

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Topics

Leukoencephalopathy, Progressive Multifocal
JC Virus
Humans
India
Male
Female
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Phylogeny

Genetic Variation

Genotype

Capsid Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41326451
DOI: 10.1038/s41598-025-26996-w
PMCID: PMC12669687

Genes

PML

Provenance

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