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Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

15 Jun 2011

Abstract excerpt

BACKGROUND: Progressive multifocal leukoencephalopathy (PML) in natalizumab-treated MS patients is linked to JC virus (JCV) infection. JCV sequence variation and rearrangements influence viral pathogenicity and tropism. To better understand PML development, we analyzed viral DNA sequences in blood, CSF and/or urine of natalizumab-treated PML patients. METHODS: Using biofluid samples from 17 natalizumab-treated...

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PMID: 21673034
DOI: 10.1093/infdis/jir256

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