Article
Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis.
The Journal of investigative dermatology - 1 Mar 2017
Blunder Stefan, Rühl Ralph, Moosbrugger-Martinz Verena, Krimmel Christine, Geisler Anita, Zhu Huiting, Crumrine Debra, Elias Peter M, Gruber Robert, Schmuth Matthias, Dubrac Sandrine
Abstract excerpt
Loss-of-function mutations in the FLG gene cause ichthyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD). Although both conditions are characterized by epidermal barrier impairment, AD also exhibits signs of inflammation. This work was aimed at delineating the role of FLG loss-of-function mutations on eicosanoid metabolism in IV and AD. Using human epidermal...
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