Article
12R-lipoxygenase deficiency disrupts epidermal barrier function.
The Journal of cell biology - 9 Apr 2007
Epp Nikolas, Fürstenberger Gerhard, Müller Karsten, de Juanes Silvia, Leitges Michael, Hausser Ingrid, Thieme Florian, Liebisch Gerhard, Schmitz Gerd, Krieg Peter
Abstract excerpt
12R-lipoxygenase (12R-LOX) and the epidermal LOX-3 (eLOX-3) constitute a novel LOX pathway involved in terminal differentiation in skin. This view is supported by recent studies showing that inactivating mutations in 12R-LOX and eLOX-3 are linked to the development of autosomal recessive congenital ichthyosis. We show that 12R-LOX deficiency in mice results in a severe impairment of skin barrier function. Loss of...
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