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Article

NANOG: A promising target for digestive malignant tumors

1 Jan 2014

Abstract excerpt

NANOG has been extensively researched since its discovery by Chambers et al. NANOG is a homeodomain transcription factor and an essential regulator of embryonic stem cell (ESC) self-renewal, which inhibits differentiation. Cancer stem cells (CSCs) are a small subset of cells that are thought to drive uncontrolled tumor growth; CSCs retain the tumor capabilities of self-renewal and propagation. The existence of...

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PMID: 25278701
DOI: 10.3748/wjg.v20.i36.13071

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