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Article

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma.

Oncotarget - 12 Jul 2016

Lee Sung Hee, Rigas Nicole Kristina, Lee Chang-Ryul, Bang April, Srikanth Sonal, Gwack Yousang, Kang Mo K, Kim Reuben H, Park No-Hee, Shin Ki-Hyuk

Abstract excerpt

Emerging evidence indicates that Orai1, a key calcium channel for store-operated Ca2+ entry, is associated with human cancer. However, the underlying mechanism by which Orai1 regulates cancer progression remains unknown. Here we report that intracellular level of Orai1 is increased in a stepwise manner during oral/oropharyngeal carcinogenesis and highly expressed in cancer stem-like cell (CSC)-enriched...

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Source

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Identifiers

PMID: 27259269
DOI: 10.18632/oncotarget.9755
PMCID: PMC5190020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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