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Article

S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53

9 Aug 2016

Abstract excerpt

Abstract S100B is one of the members of the S100 protein family and is involved in the progression of a variety of cancers. Ovarian cancer is driven by cancer stem-like cells (CSLCs) that are involved in tumorigenesis, metastasis, chemo-resistance and relapse. We then hypothesized that S100B might exert pro-tumor effects by regulating ovarian CSLCs stemness, a key characteristic of CSLCs. First, we observed the...

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PMID: 27501952
DOI: 10.1002/stem.2472

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