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A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Jun 2017

Hatae Ryusuke, Hata Nobuhiro, Suzuki Satoshi O, Yoshimoto Koji, Kuga Daisuke, Murata Hideki, Akagi Yojiro, Sangatsuda Yuhei, Iwaki Toru, Mizoguchi Masahiro, Iihara Koji

Abstract excerpt

Brain tumors harbor various BRAF alterations, the vast majority of which are the BRAF kinase-activating V600E mutation. BRAF mutations are most frequently detected in certain subtypes of low-grade glioma, such as pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA), ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNT). However, it is unclear whether gliomas harboring BRAF mutations can...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27792249
DOI: 10.1111/neup.12347

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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