Article
Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.
Circulation. Cardiovascular genetics - 1 Dec 2016
Varga Tibor V, Winters Alexandra H, Jablonski Kathleen A, Horton Edward S, Khare-Ranade Prajakta, Knowler William C, Marcovina Santica M, Renström Frida, Watson Karol E, Goldberg Ronald, Florez José C, Pollin Toni I, Franks Paul W
Abstract excerpt
BACKGROUND: We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid and lipid subfraction levels in the Diabetes Prevention Program randomized controlled trial. METHODS AND RESULTS: We tested gene treatment interactions in relation to baseline-adjusted follow-up blood lipid concentrations (high-density...
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