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Article

Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.

PLoS genetics - 1 Jan 2012

Pollin Toni I, Isakova Tamara, Jablonski Kathleen A, de Bakker Paul I W, Taylor Andrew, McAteer Jarred, Pan Qing, Horton Edward S, Delahanty Linda M, Altshuler David, Shuldiner Alan R, Goldberg Ronald B, Florez Jose C, Franks Paul W

Abstract excerpt

Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22951888
DOI: 10.1371/journal.pgen.1002895
PMCID: PMC3431328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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