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Article

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.

Cell reports - 25 Oct 2016

Alishekevitz Dror, Gingis-Velitski Svetlana, Kaidar-Person Orit, Gutter-Kapon Lilach, Scherer Sandra D, Raviv Ziv, Merquiol Emmanuelle, Ben-Nun Yael, Miller Valeria, Rachman-Tzemah Chen, Timaner Michael, Mumblat Yelena, Ilan Neta, Loven David, Hershkovitz Dov, Satchi-Fainaro Ronit, Blum Galia, Sleeman Jonathan P, Vlodavsky Israel, Shaked Yuval

Abstract excerpt

While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show that vascular endothelial growth factor receptor 3 (VEGFR3)-expressing macrophages infiltrating chemotherapy-treated tumors play a significant role in metastasis. They do so in...

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Identifiers

PMID: 27783948
DOI: 10.1016/j.celrep.2016.09.083
PMCID: PMC5098117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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