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Article

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.

Cancer cell - 4 Aug 2009

DeNardo David G, Barreto Jairo B, Andreu Pauline, Vasquez Lesley, Tawfik David, Kolhatkar Nikita, Coussens Lisa M

Abstract excerpt

During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19647220
DOI: 10.1016/j.ccr.2009.06.018
PMCID: PMC2778576

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