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Article

Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis.

Clinical and experimental immunology - 1 Mar 2017

Mariaselvam C M, Tamouza R, Krishnamoorthy R, Charron D, Misra D P, Jain V K, Negi V S

Abstract excerpt

NKG2D (KLRK1) is a C-type lectin receptor present on natural killer (NK) cells, γδ, CD8+ and CD4+ T cells. Upon ligand binding, NKG2D mediates activatory and co-stimulatory signals to NK cells and activated CD4+ T cells, respectively. Polymorphisms in NKG2D predispose to infectious diseases, cancer, transplantation and autoimmune disorders. We studied the influence of this NK receptor polymorphism on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27783394
DOI: 10.1111/cei.12891
PMCID: PMC5290229

Genes

KLRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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