Article
Autoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes.
Revista brasileira de reumatologia - 1 Jan 2000
Salim Patricia Hartstein, Jobim Mariana, Jobim Luiz Fernando, Xavier Ricardo Machado
Abstract excerpt
Killer Immunoglobulin-like Receptor (KIR) genes express as receptors that activate or inhibit Natural Killer (NK) cells. The NK cells are part of the innate immune response and, through their KIR receptors, they identify target cells that have modified or different HLA (Human Leukocyte Antigen) molecules, inducing their lysis. The KIR receptors result from the expression of KIR genes (19q13.14) on the cell...
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