Article
Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.
Circulation. Cardiovascular genetics - 1 Dec 2016
Mosley Jonathan D, van Driest Sara L, Wells Quinn S, Shaffer Christian M, Edwards Todd L, Bastarache Lisa, McCarty Catherine A, Thompson Will, Chute Christopher G, Jarvik Gail P, Crosslin David R, Larson Eric B, Kullo Iftikhar J, Pacheco Jennifer A, Peissig Peggy L, Brilliant Murray H, Linneman James G, Denny Josh C, Roden Dan M
Abstract excerpt
BACKGROUND: Continued reductions in morbidity and mortality attributable to ischemic heart disease (IHD) require an understanding of the changing epidemiology of this disease. We hypothesized that we could use genetic correlations, which quantify the shared genetic architectures of phenotype pairs and extant risk factors from a historical prospective study to define the risk profile of a contemporary IHD...
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