Article
[Ulinastatin inhibits hypoxia-induced phenotype modulation of pulmonary artery smooth muscle cells by up-regulating PPAR-γ expression].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 20 Oct 2016
Tang Kun, Liu Chang, Chen Lin, Gao Jing, Zhang Chao
Abstract excerpt
OBJECTIVE: To evaluate the effect of ulinastatin on hypoxia-induced phenotype modulation of pulmonary artery smooth muscle cells (PASMCs) and explore the underlying mechanism. METHODS: Cultured PASMCs from SD rats were exposed to normoxic condition, normoxia with ulinastatin treatment, hypoxia, or hypoxia with ulinastatin treatment. After 24 h of exposures, the cells were examined for SM-α-actin and caplonin...
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