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[Docosahexaenoic acid inhibits hypoxia-induced pulmonary arterial smooth muscle cells phenotype switching by inhibiting NFATc1 signaling].

Zhonghua xin xue guan bing za zhi - 24 Feb 2017

Xie Q F, Chen R, Lu Y, Yan J C, Liu S, Li M, Song J, Shao C, Wang Z Q, Liu P J

Abstract excerpt

Objective: To explore the molecular mechanism of docosahexaenoic acid (DHA) on regulating the phenotype switching of hypoxia-induced pulmonary arterial smooth muscle cells (PASMCs). Methods: The PASMCs were isolated from Sprague Dawley rats. PASMCs were divided into five groups: normal control group, hypoxia group (1%O(2, )94%N(2, )5% CO(2) stimulation for 12 hours), hypoxia+ DHA group (10 μmol/L DHA pretreatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28260322
DOI: 10.3760/cma.j.issn.0253-3758.2017.02.015

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