Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion

15 Jan 2019

Abstract excerpt

Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum. The neuropathological correlate of FTD is frontotemporal lobar degeneration (FTLD), characterized by tau-, TDP-43-, and FUS-immunoreactive neuronal inclusions. An earlier discovery that a hexanucleotide repeat expansion mutation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30774737
DOI: 10.1155/2019/2909168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat ExpansionPMID 30774737Read ↗

Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansionsSemantic proximity Read ↗

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.Semantic proximity Read ↗

Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum.Semantic proximity Read ↗

The Development of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia DisordersSemantic proximity Read ↗

Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesisSemantic proximity Read ↗

There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS.Semantic proximity Read ↗

RNA-mediated toxicity in C9orf72 ALS and FTDSemantic proximity Read ↗

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In VivoSemantic proximity Read ↗

Expanding Clinical Spectrum of C9ORF72 -Related Disorders and Promising Therapeutic StrategiesSemantic proximity Read ↗

Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD.Semantic proximity Read ↗

Mouse Models of C9orf72 Hexanucleotide Repeat Expansion in Amyotrophic Lateral Sclerosis/ Frontotemporal DementiaSemantic proximity Read ↗

The neuropathology associated with repeat expansions in the C9ORF72 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.