Article
BRAF V600 mutations and pathological features in Japanese melanoma patients.
Melanoma research - 1 Feb 2015
Yamazaki Naoya, Tanaka Ryota, Tsutsumida Arata, Namikawa Kenjiro, Eguchi Hironobu, Omata Wataru, Oashi Kohei, Ogawa Toru, Hayashi Amiko, Nakamura Noriyuki, Tsuta Koji
Abstract excerpt
Ultraviolet radiation is a risk factor for BRAF V600 mutations frequently found in melanomas that cause constitutive BRAF activation. Primary sites of melanoma and the frequency of BRAF mutations might differ between races. Melanoma is rare in Japan (1500-2000 cases/year compared with 132 000/year worldwide) and the frequency and distribution of BRAF V600 mutations are unknown. We aimed to investigate the...
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