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<i>L</i> -5-[11C]-glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine Metabolism

2026-07-03

Abstract excerpt

<h4>Background</h4> Glutamine addiction is a hallmark of aggressive tumors, yet glutaminase (GLS1) inhibitor CB-839 showed disappointing anti-tumor efficacy in clinical trials. L -5-[¹¹C]-glutamine ([¹¹C]glutamine) PET enables non-invasive assessment of glutamine metabolism in vivo , providing a tool to test mechanistic hypotheses, and identify tumors likely to respond to GLS1 inhibition: focusing on compartm...

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Literature Corpus work
baf5babd-e4e0-55ac-85d5-7bad13dab0dd
DOI
10.64898/2026.07.02.736194
Open publication

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<i>L</i> -5-[11C]-glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine MetabolismDOI 10.64898/2026.07.02.736194
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