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Article

Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer.

International journal of molecular sciences - 27 Jul 2017

Toda Kosuke, Nishikawa Gen, Iwamoto Masayoshi, Itatani Yoshiro, Takahashi Ryo, Sakai Yoshiharu, Kawada Kenji

Abstract excerpt

Mutation in the KRAS gene induces prominent metabolic changes. We have recently reported that KRAS mutations in colorectal cancer (CRC) cause alterations in amino acid metabolism. However, it remains to be investigated which amino acid transporter can be regulated by mutated KRAS in CRC. Here, we performed a screening of amino acid transporters using quantitative reverse-transcription polymerase chain reaction...

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Source

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Identifiers

PMID: 28749408
DOI: 10.3390/ijms18081632
PMCID: PMC5578022

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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