Article
Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread.
Cell - 20 Oct 2016
Lamason Rebecca L, Bastounis Effie, Kafai Natasha M, Serrano Ricardo, Del Álamo Juan C, Theriot Julie A, Welch Matthew D
Abstract excerpt
Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical force for spread. Here, we show that SFG species Rickettsia parkeri typically lack actin tails...
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