Article
Critical Role for Heat Shock Protein 20 (HSP20) in Migration of Malarial Sporozoites
3 Dec 2011
Abstract excerpt
Plasmodium sporozoites, single cell eukaryotic pathogens, use their own actin/myosin-based motor machinery for life cycle progression, which includes forward locomotion, penetration of cellular barriers, and invasion of target cells. To display fast gliding motility, the parasite uses a high turnover of actin polymerization and adhesion sites. Paradoxically, only a few classic actin regulatory proteins appear to...
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