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Article

Dom34 Links Translation to Protein O-mannosylation.

PLoS genetics - 1 Oct 2016

van Wijlick Lasse, Geissen René, Hilbig Jessica S, Lagadec Quentin, Cantero Pilar D, Pfeifer Eugen, Juchimiuk Mateusz, Kluge Sven, Wickert Stephan, Alepuz Paula, Ernst Joachim F

Abstract excerpt

In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits. We found that in the yeast Saccharomyces cerevisiae and the human fungal pathogen Candida albicans, Dom34 interacts genetically with Pmt1, a major isoform of protein O-mannosyltransferase. In C. albicans, lack of Dom34 exacerbated defective phenotypes of pmt1 mutants, while they were ameliorated by Dom34...

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Share to Candida albicans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

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Source

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Identifiers

PMID: 27768707
DOI: 10.1371/journal.pgen.1006395
PMCID: PMC5074521

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