Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intensive 'Brain Training' Intervention Fails to Reduce Amyloid Pathologies or Cognitive Deficits in Transgenic Mouse Models of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Anderson Maria, Xu Feng, Ou-Yang Ming-Hsuan, Davis Judianne, Van Nostrand William E, Robinson John K

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the leading cause of dementia in the elderly. Amyloid-β protein (Aβ) depositions in both the brain parenchyma and the cerebral vasculature are recognized as important pathological components that contribute to the cognitive impairments found in individuals with AD. Because pharmacological options have been minimally effective in treating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Cognitive Behavioral Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maze Learning

Share to Memory, Short-Term

Share to Microvessels

Share to Presenilin-1

Share to Reaction Time

Share to Reinforcement, Psychology

Source

Identifiers

PMID: 27767989
DOI: 10.3233/JAD-160674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intensive 'Brain Training' Intervention Fails to Reduce Amyloid Pathologies or Cognitive Deficits in Transgenic Mouse Models of Alzheimer's Disease.PMID 27767989Read ↗

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathologySemantic proximity Read ↗

Examining Alzheimer's Disease modifiable risk factors: Impact of physical activity and diet on neuroanatomy and behaviour in mouse modelsSemantic proximity Read ↗

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse modelSemantic proximity Read ↗

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Mouse PAW: reverse-translating the FINGER multimodal lifestyle intervention enhances synaptic plasticity and cognition in adult wild type female miceSemantic proximity Read ↗

High-Intensity Interval Training Modulates APP Expression and Reduces Neuronal Apoptosis in a β-Amyloid-Induced Model of Alzheimer’s Disease: Hippocampal EvidenceSemantic proximity Read ↗

Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice.Semantic proximity Read ↗

Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model.Semantic proximity Read ↗

Aerobic exercise during exposure to 40Hz light flicker protects against early cognitive impairments in Alzheimer’s disease of 3xTg miceSemantic proximity Read ↗

Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity.Semantic proximity Read ↗

Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice.Semantic proximity Read ↗

Pre-amyloid cognitive intervention preserves brain function in aged TgF344-AD rats, maintaining connectivity and enhancing plasticity in a sex-specific mannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.