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Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity.

Cells - 20 Mar 2021

Wierczeiko Anna, Gammel Lena, Radyushkin Konstantin, Nguyen Vu Thu Thuy, Todorov Hristo, Gerber Susanne, Endres Kristina

Abstract excerpt

Physical activity is considered a promising preventive intervention to reduce the risk of developing Alzheimer's disease (AD). However, the positive effect of therapeutic administration of physical activity has not been proven conclusively yet, likely due to confounding factors such as varying activity regimens and life or disease stages. To examine the impact of different routines of physical activity in the...

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PMID: 33804749
DOI: 10.3390/cells10030693
PMCID: PMC8004053

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