Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inter-individual gene variants associated with trabecular bone plasticity: A step forward in the personal genomics of degenerative bone disease.

Injury - 1 Nov 2017

Caso Enrique, Sabiers Cristina C, López-Guillén Daniel, Caso Jaime, Toledano Manuel, Osorio Raquel, Osorio Estrella, Lozano Carmen, Guerado Enrique

Abstract excerpt

Continuing tissue destruction in osteoarthrosis is maintained by molecular pathways related to an unbalanced chondrocyte metabolism, the loss of reactive oxygen species (ROS) homeostasis, increase catabolism in a degraded matrix and the limited response to growth factors due to cell aging. Rare deleterious gene variants driving relevant molecular pathways may play a key role in the pathogenesis and genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type I
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genomics

Share to Osteoarthritis

Share to Osteogenesis

Share to Osteonecrosis

Source

Identifiers

PMID: 29162237
DOI: 10.1016/S0020-1383(17)30790-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inter-individual gene variants associated with trabecular bone plasticity: A step forward in the personal genomics of degenerative bone disease.PMID 29162237Read ↗

Identification of novel genetic variations affecting osteoarthritis patients.Semantic proximity Read ↗

Whole-exome sequencing: discovering genetic causes of orthopaedic disorders.Semantic proximity Read ↗

The genetic architecture of osteoarthritis: insights from UK BiobankSemantic proximity Read ↗

The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?Semantic proximity Read ↗

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Semantic proximity Read ↗

Non-COL1A1/2 genetic burden and osteoporosis-overlap in patients referred with osteogenesis imperfecta phenotype.Semantic proximity Read ↗

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.Semantic proximity Read ↗

Identification of Novel Genetic Variants Associated with Knee Osteoarthritis Patients of South India using Whole Exome SequencingSemantic proximity Read ↗

The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease.Semantic proximity Read ↗

The genetic epidemiology of human primary osteoarthritis: current statusSemantic proximity Read ↗

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritisSemantic proximity Read ↗

Structural phenotypes of osteoarthritis are clinically and genetically distinct: findings from 59,539 UK Biobank participantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.