Sexual Dimorphism and Aging in the Human Hyppocampus: Identification, Validation, and Impact of Differentially Expressed Genes by Factorial Microarray and Network Analysis

Abstract excerpt

Motivation: In the brain of elderly-healthy individuals, the effects of sexual dimorphism and those due to normal ageing appear overlapped. Discrimination of these two dimensions would powerfully contribute to a better understanding of the aetiology of some neurodegenerative diseases, such as “sporadic” Alzheimer. Methods: Following a system biology approach, top-down and bottom-up strategies were combined....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Genetics, Aging, and Longevity in Model Organisms