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Article

Delayed diagnosis of pituitary LCH with BRAFV600E mutation: A case report and literature review.

Medicine - 17 Oct 2025

Hou Yiwei, Yang Yu, Liao Xiangyu, Yi Li, Li Shixin, Li Beihan, Fu Yunxi, Zhou Zijun, Tong Mingxu, Zhu Wufei

Abstract excerpt

RATIONALE: This case report highlights the diagnostic challenges and clinical complexities of adult-onset pituitary Langerhans Cell Histiocytosis (LCH), a rare entity with a prolonged and indolent progression. This underscores the critical need for heightened clinical suspicion in patients with chronic endocrine dysfunction, particularly in those with multisystem comorbidities. The atypical 10-year diagnostic...

Read the complete abstract on PubMed

Topics

Humans
Female
Adult
Histiocytosis, Langerhans-Cell
Delayed Diagnosis
Pituitary Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Mutation

Magnetic Resonance Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 41189157
DOI: 10.1097/MD.0000000000045274
PMCID: PMC12537124

Genes

PRL

Provenance

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