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Progranulin Gene Mutations in Chinese Patients with Frontotemporal Dementia: A Case Report and Literature Review.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Chu Min, Nan Haitian, Jiang Deming, Liu Li, Huang Anqi, Wang Yihao, Wu Liyong

Abstract excerpt

BACKGROUND: Progranulin (GRN) mutations in frontotemporal dementia (FTD) have been less frequently reported in China than in Western countries. OBJECTIVE: This study reports a novel GRN mutation and summarizes the genetic and clinical features of patients with GRN mutations in China. METHODS: Comprehensive clinical, genetic, and neuroimaging examinations were conducted on a 58-year-old female patient diagnosed...

Topics

Humans
Female
Male
Progranulins
Frontotemporal Dementia
Intercellular Signaling Peptides and Proteins
East Asian People
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36970912
DOI: 10.3233/JAD-230052
PMCID: PMC10200209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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