Article
Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing.
BMC medical genomics - 19 Oct 2016
Wei Lei, Papanicolau-Sengos Antonios, Liu Song, Wang Jianmin, Conroy Jeffrey M, Glenn Sean T, Brese Elizabeth, Hu Qiang, Miles Kiersten Marie, Burgher Blake, Qin Maochun, Head Karen, Omilian Angela R, Bshara Wiam, Krolewski John, Trump Donald L, Johnson Candace S, Morrison Carl D
Abstract excerpt
BACKGROUND: The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neoplastic tissue adjacent to the excised neoplasm is often used for this purpose as it is simultaneously collected and...
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