Article

Achieving reproducibility and accuracy in cancer mutation detection with whole-genome and whole-exome sequencing

2019-05-03

Abstract excerpt

Clinical applications of precision oncology require accurate tests that can distinguish tumor-specific mutations from errors introduced at each step of next generation sequencing (NGS). For NGS to successfully improve patient lives, discriminating between true mutations and artifacts is crucial. We systematically interrogated somatic mutations in paired tumor-normal cell lines to identify factors affecting detecti...

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Literature Corpus work: 9d1b0b86-e47d-587d-8541-147c970e6385
DOI: 10.1101/626440

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