Article
The Impact of Superoxide Dismutase-1 Genetic Variation on Cardiovascular and All-Cause Mortality in a Prospective Cohort Study: The Yamagata (Takahata) Study.
PloS one - 1 Jan 2016
Otaki Yoichiro, Watanabe Tetsu, Nishiyama Satoshi, Takahashi Hiroki, Arimoto Takanori, Shishido Tetsuro, Miyamoto Takuya, Konta Tsuneo, Shibata Yoko, Sato Hidenori, Kawasaki Ryo, Daimon Makoto, Ueno Yoshiyuki, Kato Takeo, Kayama Takamasa, Kubota Isao
Abstract excerpt
BACKGROUND: Oxidative stress is a major cause of cardiovascular disease. Superoxide dismutase-1 (SOD1) is an antioxidant that protects against oxidative stress. Deoxyribonucleic acid (DNA) variations such as single nucleotide polymorphism (SNP) or haplotypes within the SOD gene are reportedly associated with the development of cardiovascular disease. However, it remains to be determined whether SOD1 variability...
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