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Article

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir

15 Oct 2016

Abstract excerpt

OBJECTIVE: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-treated patients to make latent cells visible to the host immune system. Stimulation of patient cell cultures with latency-reversing agents (LRAs) ex vivo results in heterogeneous responses among HIV-infected...

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PMID: 27755105
DOI: 10.1097/qad.0000000000001290

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