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Article

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

30 May 2013

Abstract excerpt

HIV-1 persists in infected individuals in a stable pool of resting CD4(+) T cells as a latent but replication-competent provirus. This latent reservoir is the major barrier to the eradication of HIV-1. Clinical trials are currently underway investigating the effects of latency-disrupting compounds on the persistence of the latent reservoir in infected individuals. To accurately assess the effects of such...

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PMID: 23737751
DOI: 10.1371/journal.ppat.1003398

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