Impact of the Genetics and Source of Preclinical Safety Animal Models on Study Design, Results, and Interpretation.

Abstract excerpt

It has been long established that not only the species but also the strain and supplier of rodents used in preclinical safety studies can have a significant impact on the outcome of studies due to variability in their genetic background and thus spontaneous pathologic findings. In addition, local husbandry, housing, and other environmental conditions may have effects on the development and expression of...

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