Article
Reproducibility and replicability of rodent phenotyping in preclinical studies.
Neuroscience and biobehavioral reviews - 1 Apr 2018
Kafkafi Neri, Agassi Joseph, Chesler Elissa J, Crabbe John C, Crusio Wim E, Eilam David, Gerlai Robert, Golani Ilan, Gomez-Marin Alex, Heller Ruth, Iraqi Fuad, Jaljuli Iman, Karp Natasha A, Morgan Hugh, Nicholson George, Pfaff Donald W, Richter S Helene, Stark Philip B, Stiedl Oliver, Stodden Victoria, Tarantino Lisa M, Tucci Valter, Valdar William, Williams Robert W, Würbel Hanno, Benjamini Yoav
Abstract excerpt
The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and...
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