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Article

Translating animal model research: does it matter that our rodents are cold?

Physiology (Bethesda, Md.) - 1 Nov 2014

Maloney Shane K, Fuller Andrea, Mitchell Duncan, Gordon Christopher, Overton J Michael

Abstract excerpt

Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and...

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Share to Body Temperature Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Housing, Animal

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Share to Translational Research, Biomedical

Source

Identifiers

PMID: 25362635
DOI: 10.1152/physiol.00029.2014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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