Article
mFast-SeqS as a Monitoring and Pre-screening Tool for Tumor-Specific Aneuploidy in Plasma DNA.
Advances in experimental medicine and biology - 1 Jan 2016
Belic Jelena, Koch Marina, Ulz Peter, Auer Martina, Gerhalter Teresa, Mohan Sumitra, Fischereder Katja, Petru Edgar, Bauernhofer Thomas, Geigl Jochen B, Speicher Michael R, Heitzer Ellen
Abstract excerpt
Recent progress in the analysis of cell-free DNA fragments (cell-free circulating tumor DNA, ctDNA) now allows monitoring of tumor genomes by non-invasive means. However, previous studies with plasma DNA from patients with cancer demonstrated highly variable allele frequencies of ctDNA. Comprehensive genome-wide analysis of tumor genomes is greatly facilitated when plasma DNA has increased amounts of ctDNA. In...
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