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Circulating tumor DNA in cancer: Predictive molecular pathology meets mathematics.

Critical reviews in oncology/hematology - 1 Jul 2021

Malapelle Umberto, Buono Mauro, Pisapia Pasquale, Russo Gianluca, Tufano Rossella, Pepe Francesco, Rolfo Christian, Troncone Giancarlo

Abstract excerpt

The cancer secretome is a valuable reservoir of cancer biomarkers. Besides containing circulating tumor cells, extracellular vesicles, and proteins, it is also rich in circulating tumor DNA (ctDNA)-a subpopulation of cell free DNA. The most efficient technology to capture ctDNA is next generation sequencing (NGS). Indeed, this analysis enables the identification of both quantitative (e.g., mutant allelic fraction...

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PMID: 34119656
DOI: 10.1016/j.critrevonc.2021.103394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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