Article
Detection of p53 Mutations in Circulating DNA of Transplanted Hepatocellular Carcinoma Patients as a Biomarker of Tumor Recurrence.
Advances in experimental medicine and biology - 1 Jan 2016
García-Fernández N, Macher Hada C, Rubio Amalia, Jiménez-Arriscado Pilar, Bernal-Bellido C, Bellido-Díaz M L, Suárez-Artacho G, Guerrero Juan M, Gómez-Bravo M A, Molinero Patrocinio
Abstract excerpt
p53 is the most commonly mutated gene in malignant human cancers. To detect p53 mutations in circulating DNA (cirDNA) of transplanted hepatocellular carcinoma (HCC) patients could be an interesting approach to know of any tumor recurrence. In this study, our objective was to determine the utility of this method in the diagnosis and the prognosis of HCC tumor recurrence.Twenty four liver transplanted HCC patients...
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