Article
MDR1 gene polymorphisms and risk of recurrence in patients with hepatocellular carcinoma after liver transplantation.
Journal of surgical oncology - 1 Jul 2007
Wu Liming, Xu Xiaobo, Shen Juwei, Xie Haiyang, Yu Songfeng, Liang Tingbo, Wang Weilin, Shen Yan, Zhang Min, Zheng Shusen
Abstract excerpt
BACKGROUND AND OBJECTIVES: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains a major cause of post-LT death. However, currently there is still lacking the markers to reliably predict recurrence. This study was undertaken to evaluate the association between three polymorphisms (C1236T, G2677A/T, C3435T) of Multidrug resistance 1 (MDR1) gene and the risk of recurrence after LT....
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adolescent
- Adult
- Aged
- Carcinoma, Hepatocellular
- Female
- Genes, MDR
- Genotype
- Humans
- Liver Neoplasms
- Liver Transplantation
- Male
- Middle Aged