Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation.

doi:10.1371/journal.pone.0026003

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Article

Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation.

PloS one - 1 Jan 2011

Hu Jie, Wang Zheng, Fan Jia, Dai Zhi, He Yi-Feng, Qiu Shuang-Jian, Huang Xiao-Wu, Sun Jian, Xiao Yong-Sheng, Song Kang, Shi Ying-Hong, Sun Qi-Man, Yang Xin-Rong, Shi Guo-Ming, Yu Lei, Yang Guo-Huan, Ding Zhen-Bin, Gao Qiang, Tang Zhao-You, Zhou Jian

Abstract excerpt

BACKGROUND: Recurrence prediction of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) present a great challenge because of a lack of biomarkers. Genetic variations play an important role in tumor development and metastasis. METHODS: Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients...

Topics

Carcinoma, Hepatocellular
DNA
Female
Genetic Variation
Genotyping Techniques
Hepatitis B virus
Humans
Liver Neoplasms
Liver Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Metastasis

Oligonucleotide Array Sequence Analysis

Prognosis

ROC Curve

Recurrence

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 21998744
DOI: 10.1371/journal.pone.0026003
PMCID: PMC3187841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21998744-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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