Comprehensive genomic characterization of early-stage bladder cancer.

doi:10.1038/s41588-024-02030-z

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Article

Comprehensive genomic characterization of early-stage bladder cancer.

Nature genetics - 1 Jan 2025

Prip Frederik, Lamy Philippe, Lindskrog Sia Viborg, Strandgaard Trine, Nordentoft Iver, Birkenkamp-Demtröder Karin, Birkbak Nicolai Juul, Kristjánsdóttir Nanna, Kjær Asbjørn, Andreasen Tine G, Ahrenfeldt Johanne, Pedersen Jakob Skou, Rasmussen Asta Mannstaedt, Hermann Gregers G, Mogensen Karin, Petersen Astrid C, Hartmann Arndt, Grimm Marc-Oliver, Horstmann Marcus, Nawroth Roman, Segersten Ulrika, Sikic Danijel, van Kessel Kim E M, Zwarthoff Ellen C, Maurer Tobias, Simic Tatjana, Malmström Per-Uno, Malats Núria, Jensen Jørgen Bjerggaard, Real Francisco X, Dyrskjøt Lars

Abstract excerpt

Understanding the molecular landscape of nonmuscle-invasive bladder cancer (NMIBC) is essential to improve risk assessment and treatment regimens. We performed a comprehensive genomic analysis of patients with NMIBC using whole-exome sequencing (n = 438), shallow whole-genome sequencing (n = 362) and total RNA sequencing (n = 414). A large genomic variation within NMIBC was observed and correlated with different...

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Identifiers

PMID: 39753772
DOI: 10.1038/s41588-024-02030-z
PMCID: PMC11735393

Genes

FGFR3
TP53

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