Article
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia.
British journal of haematology - 1 Jan 2017
Sainio Susanna, Javela Kaija, Tuimala Jarno, Haimila Katri
Abstract excerpt
Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Despite the long-known association between the HLA-DRB3*01:01 allele and human platelet antigen 1a (HPA-1a) alloimmunisation, maternal human leucocyte antigen (HLA) typing has been of little clinical value. Recently, other DRB3 allele variants have been suggested to predict the...
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