Article
Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
Transfusion - 1 Feb 2013
Loewenthal Ron, Rosenberg Nurit, Kalt Rivka, Dardik Rima, Landau Meytal, Yahalom Vered, Avishai Ofelia, Frenkel Orit, Gazit Ephraim, Steinberg David M, Lipitz Shlomo, Salomon Ophira
Abstract excerpt
BACKGROUND: Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder in the fetus or neonate caused by maternal alloantibodies directed against fetal platelet (PLT) antigens inherited from the father. The immune-dominant antigen leading to severe FNAIT is the human PLT antigen (HPA)-1, whose polymorphism constitutes an epitope for human leukocyte antigens (HLAs), usually...
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